Based on our vision of employing on Molecule-Activation Chemistry for Advanced Systems Biology, we propose the following research consisting of three core projects.
I) Control of Biological Systems: Development of molecules that precisely control biotic productivity and quality
(a) Molecules that dramatically enhance plant growth
(b) Molecules that improve animal reproduction innovatively
(c) Molecules that overcome the genome barrier to produce novel crops
II) Visualization of Biological Systems: Development of molecules that permit innovative bio-imaging
(a) Target biological models
(b) Highly efficient, full-color fluorescent molecules
(c) Specific conjugation technologies
III) Synthesis of New Bio-Functional Molecules: Development of catalysts that enable incredibly efficient synthesis and molecule-activation on demand
(a) Catalysts activating C-H bonds
(b) Catalysts acting without heavy metals
(c) Catalysts for protein ligation
(d) Catalysts for in vivo chemical transformations
Research project (I) aims to precisely control biological systems. We will utilize all the outcomes obtained in ITbM to accomplish this objective. Research project (II) aims to visualize biological systems at will. The outcome of this research project (II) will have a significant impact on a wide range of life science-related fields. At the same time, it accelerates research project (I). In research project (III), we will develop small-molecule catalysts for achieving ideal chemical synthesis. This is the core of ITbM and provides viable methods for realizing both projects (I) and (II). In addition to these, feedback from projects (I) and (II) further promotes the development of catalysts in project (III). Thus, the three core research projects are closely integrated. Importantly, progress in these core projects will together result in the development of transformative bio-molecules.