The research group of Florence Tama focuses on the computational studies of the structures and functions of large macromolecular assemblies. Dysfunctions of these bio-molecules may result in severe diseases and in order to understand such diseases and develop treatments, the functional mechanisms of these bio-molecules need to be elucidated. To this goal, Tama's group 1) develops new computational techniques to determine 3D structures and dynamics of biological complexes and 2) works in collaboration with experimental groups to elucidate functions of bio-molecules of interest.