Junichiro Yamaguchi
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Profile
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Junichiro Yamaguchi
Collaborating Investigator, Associate Professor (Nagoya University)
Website
junichiro::chem.nagoya-u.ac.jp
Synthetic Chemistry, Natural Product Synthesis, Catalysis
My research program has focused on synthesis-oriented methodology development in catalytic C-H coupling (direct arene-assembling reactions). As a result, more than ten new C-H coupling reactions of heteroarenes such as 1,3-azoles, indoles, pyrroles, azines and thiophenes have been developed and utilized for the rapid synthesis of bioactive molecules such as natural products and pharmaceutical candidates. Furthermore, the method of late-stage C-H coupling can be highly relevant for medicinal chemistry.
Research Highlights:
- A novel "Kabuto-like" nickel catalyst forms bioactive frameworks from low-cost phenol derivatives
- Chemists uncover new role of a key base in organic synthesis
- Selective Functionalization Synthesizes Chemotherapeutic Natural Products
- Programmed Synthesis towards Multi-substituted Benzene Derivatives
- Small molecules change biological clock rhythm
- Aromatic couple makes new chemical bonds