Research Highlights

One hormone, two roles: Sugars differentiate seasonality and metabolism

Abstract:

Professor Takashi Yoshimura and colleagues at ITbM, Nagoya University and the University of Chicago have discovered the mechanism on how a single hormone manages to trigger two different functions, i.e. seasonal sensing and metabolism, without any cross activity.

　　　　　Mouse measuring the seasonal time 　　　　 　Image showing selective capture of PT-TSH　　　　　　

　 Structure of hypothalamus and pituitary gland　　　　　Mechanism of TSH playing two roles

Journal Information:

"Tissue-specific post-translational modification allows functional targeting of thyrotropin" by Keisuke Ikegami, Xiao-Hui Liao, Yuta Hoshino, Hiroko Ono, Wataru Ota, Yuka Ito, Taeko Nishiwaki-Ohkawa, Chihiro Sato, Ken Kitajima, Masayuki Iigo, Yasufumi Shigeyoshi, Masanobu Yamada, Yoshiharu Murata, Samuel Refetoff, Takashi Yoshimura is published online on October 30, 2014 in Cell Reports.

DOI:10.1016/j.celrep.2014.10.006

Cell Reports

Selected as cover image

Links:

• Press Release

• Nagoya University Research

Professor Takashi Yoshimura: http://www.itbm.nagoya-u.ac.jp/en_backup/members/t-yoshimura/

Prof. Yoshimura

　　　　　　　　

Media Coverage and Related Links:

• EurekAlert! "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
• Medical xPress "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
• Biocompare "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
• Medical Daily "Thyroid Hormone Thyrotropin Plays Dual Role In Metabolism And Sensing Seasonal Changes Without Confusion" (Oct 30, 2014)
• Science Newsline "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
• Science Daily "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
• Science Codex "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
• EurekAlert! Chinese "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 31, 2014)
• Media India "How Does a Single Hormone Manage to Trigger Two Different Functions?" (Oct 31, 2014)
• lequotidiendumedecin (French) "La TSH se « sucre » pour jouer un rôle dans le métabolisme ou la saisonnalité" (Oct 31, 2014)
• Una hormona, funciones diferentes y vitales featured in diariomedico (Spanish), herenciageneticayenfermedad (Spanish) (Oct 31, 2014)
• One hormone, 2 roles: Sugars differentiate seasonality and metabolism featured in "China Medical Tribune (Chinese)", "Sci Today (Chinese)" (Nov 3, 2014)
• Medical News Today "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Nov 3, 2014)
• ResearchSEA "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 31, 2014)
• Asian Scientist "How A Single Hormone Plays Two Roles" (Nov 6, 2014)
• The Visible Embryo "Sugars help us differentiate seasons" (Nov 10, 2014)

2014-10-31

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