Research Highlights
One hormone, two roles: Sugars differentiate seasonality and metabolism
Abstract:
Professor Takashi Yoshimura and colleagues at ITbM, Nagoya University and the University of Chicago have discovered the mechanism on how a single hormone manages to trigger two different functions, i.e. seasonal sensing and metabolism, without any cross activity.


Mouse measuring the seasonal time Image showing selective capture of PT-TSH


Structure of hypothalamus and pituitary gland Mechanism of TSH playing two roles
Journal Information:
"Tissue-specific post-translational modification allows functional targeting of thyrotropin" by Keisuke Ikegami, Xiao-Hui Liao, Yuta Hoshino, Hiroko Ono, Wataru Ota, Yuka Ito, Taeko Nishiwaki-Ohkawa, Chihiro Sato, Ken Kitajima, Masayuki Iigo, Yasufumi Shigeyoshi, Masanobu Yamada, Yoshiharu Murata, Samuel Refetoff, Takashi Yoshimura is published online on October 30, 2014 in Cell Reports.
DOI:10.1016/j.celrep.2014.10.006
Links:
- Press Release
- Nagoya University Research
- EurekAlert! "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
- Medical xPress "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
- Biocompare "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
- Medical Daily "Thyroid Hormone Thyrotropin Plays Dual Role In Metabolism And Sensing Seasonal Changes Without Confusion" (Oct 30, 2014)
- Science Newsline "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
- Science Daily "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
- Science Codex "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 30, 2014)
- EurekAlert! Chinese "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 31, 2014)
- Media India "How Does a Single Hormone Manage to Trigger Two Different Functions?" (Oct 31, 2014)
- lequotidiendumedecin (French) "La TSH se « sucre » pour jouer un rôle dans le métabolisme ou la saisonnalité" (Oct 31, 2014)
- Una hormona, funciones diferentes y vitales featured in diariomedico (Spanish), herenciageneticayenfermedad (Spanish) (Oct 31, 2014)
- One hormone, 2 roles: Sugars differentiate seasonality and metabolism featured in "China Medical Tribune (Chinese)", "Sci Today (Chinese)" (Nov 3, 2014)
- Medical News Today "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Nov 3, 2014)
- ResearchSEA "One hormone, 2 roles: Sugars differentiate seasonality and metabolism" (Oct 31, 2014)
- Asian Scientist "How A Single Hormone Plays Two Roles" (Nov 6, 2014)
- The Visible Embryo "Sugars help us differentiate seasons" (Nov 10, 2014)

Professor Takashi Yoshimura: http://www.itbm.nagoya-u.ac.jp/en_backup/members/t-yoshimura/

Media Coverage and Related Links:
2014-10-31