ISTbM-8 Invited Lecturer
Professor at the University of Oxford, Department of Chemistry (Mathematical, Physical and Life Sciences Division)
and Tutorial Fellowship at Merton College (Oxford)
Date:February (Wed) 2nd, 2022
Time: 17:55 - 18:25
Hydrogen Bonding Phase Transfer Catalysis for Fluorination and Beyond
Understanding and controlling fluoride reactivity is crucial to progress the development of catalytic fluorination processes using cost effective metal alkali fluoride. We recently disclosed a solution to these problems, inspired by the mode of action of the fluorinase enzyme. Specifically, we discovered that a hydrogen bond donor such as a chiral urea is capable of transporting unreactive solid CsF into solution in the form of a soluble reactive chiral urea-fluoride complex enabling asymmetric carbon-fluorine bond formation. This new catalysis manifold coined Hydrogen Bonding Phase Transfer Catalysis has the potential to be applied to nucleophilic reagents other than metal alkali fluoride. This research is part of our program on sustainable fluorine chemistry including the development of more efficient fluorination processes, and the recycling/repurposing of fluorinated materials.