21)

Miller, S., Kesherwani, M., Chan, P., Nagai, Y., Yagi, M., Cope, J., Tama, F., Kay, S.A. ^*, and Hirota, T.^*: CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy.
Proc. Natl. Acad. Sci. USA, 119: e2203936119 (2022)
プレスリリース

20)

Yagi, M. ^#, Miller, S. ^#, Nagai, Y. ^#, Inuki, S., Sato, A., and Hirota, T.^*: A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins.
F1000Res, 11: 1016 (2022)
Special collection "Circadian Clocks in Health and Disease" (Takahashi, J.S. and Green, C.B. eds.)

19)

Iida, M., Nakane, Y., Yoshimura, T. ^*, and Hirota, T.^*: Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish.
J.Biochem., 171: 501-507 (2022)
Special issue "Molecular connections between circadian clock and health/aging" (Nakahata, Y. and Fukada, Y. eds.)

18)

Miller, S. ^#, Srivastava, A. ^#, Nagai, Y., Aikawa, Y., Tama, F., and Hirota, T.^*: Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.
Proc. Natl. Acad. Sci. USA, 118: e2026191118 (2021)
プレスリリース

17)

Kolarski, D., Vinyals, C.M. ^#, Sugiyama, A. ^#, Srivastava, A., Ono, D., Nagai, Y., Iida, M., Itami, K., Tama, F., Szymanski, W. ^*, Hirota, T.^*, and Feringa, B.L. ^*: Reversible modulation of circadian time with chronophotopharmacology.
Nature Commun., 12: 3164 (2021)
Featured in Nature Communications Editors' Highlights
Featured in Katsnelson, A.: Light activated molecule shifts circadian clock in cells. C&EN 99:22 (2021)
プレスリリース

16)

Kolarski, D. ^#, Miller, S. ^#, Oshima, T. ^#, Nagai, Y., Aoki, Y., Kobauri, P., Srivastava, A., Sugiyama, A., Amaike, K., Sato, A., Tama, F., Szymanski, W., Feringa, B.L. ^*, Itami, K. ^*, Hirota, T.^*: Photopharmacological manipulation of mammalian CRY1 for regulation of the circadian clock.
J. Am. Chem. Soc., 143: 2078-2087 (2021)
プレスリリース

15)

Miller, S. ^#, Aikawa, Y. ^#, Sugiyama, A., Nagai, Y., Hara, A., Oshima, T., Amaike, K., Kay, S.A., Itami, K., and Hirota, T.^*: An isoform-selective modulator of Cryptochrome 1 regulates circadian rhythms in mammals.
Cell Chem. Biol., 27: 1192-1198 (2020)
Featured in Crane, B.R.: Winding down: Selectively drugging a promiscuous pocket in Cryptochrome slows circadian rhythms. Cell Chem. Biol., 27: 1109-1111 (2020) [Previews]

14)

Miller, S. ^#, Son, Y.L. ^#, Aikawa, Y. ^#, Makino, E., Nagai, Y., Srivastava, A., Oshima, T., Sugiyama, A., Hara, A., Abe, K., Hirata, K., Oishi, S., Hagihara, S., Sato, A., Tama, F., Itami, K., Kay, S.A., Hatori, M. ^*, and Hirota, T.^*: Isoform-selective regulation of mammalian cryptochromes.
Nature Chem. Biol., 16: 676-685 (2020)
Featured in Lara, J. and Zoltowski, B.D.: A tail of CRY selectivity. Nat. Chem. Biol., 16: 608-609 (2020) [news & views]
Featured in: 15 years of Nature Chemical Biology. Nat. Chem. Biol., 16: 597 (2020) [editorial]
プレスリリース

13)

Kolarski, D., Sugiyama, A., Breton, G., Rakers, C., Ono, D., Schulte, A., Tama, F., Itami, K., Szymanski, W., Hirota, T.^*, and Feringa, B.L. ^*: Controlling the circadian clock with high temporal resolution through photodosing.
J. Am. Chem. Soc., 141: 15784-15791 (2019)
プレスリリース

12)

Lee, J.W. ^#,*, Hirota, T.^#,*, Ono, D., Honma, S., Honma, K.I., Park, K., and Kay, S.A.: Chemical control of mammalian circadian behavior through dual inhibition of casein kinase Iα and δ.
J. Med. Chem., 62: 1989-1998 (2019)

11)

Oshima, T. ^#, Niwa, Y. ^#, Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y., Yagita, K., Ikeda, M., Kinoshita, T., Kay, S.A., Itami, K.^*, and Hirota, T.^*:Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.
Science Advances, 5: eaau9060 (2019)
プレスリリース

10)

Qu, M., Duffy, T., Hirota, T., and Kay, S.A. ^*: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks.
Proc. Natl. Acad. Sci. USA, 115: E12305-E12312 (2018)

9)

Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L., Lamia, K., Liu, S., Atkins, A.R., Banayo, E., Liddle, C., Yu, R.T., Yates III, J.R., Kay, S.A., Downes, M. ^*, and Evans, R.M. ^*: Circadian amplitude regulation via FBXW7-targeted REV-ERBα degradation.
Cell, 165: 1644-1657 (2016)

8)

Lee, J.W.^#, Hirota, T.^#,*, Kumar, A. ^#,*, Kim, N.J., Irle, S., and Kay, S.A. ^*: Development of small molecule Cryptochrome stabilizer derivatives as modulators of the circadian clock.
ChemMedChem, 10: 1489-1497 (2015)
Cover article

7)

St. John, P.C., Hirota, T., Kay, S.A. ^*, and Doyle, F.J. 3rd^*: Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock.
   Proc. Natl. Acad. Sci. USA, 111: 2040-2045 (2014)

6)

Hirota, T., Lee, J.W., St. John, P.C., Sawa, M., Iwaisako, K., Noguchi, T., Pongsawakul, P.Y., Sonntag, T., Welsh, D.K., Brenner, D.A., Doyle, F.J. 3rd, Schultz, P.G. ^*, and Kay, S.A. ^*: Identification of small molecule activators of cryptochrome.
Science, 337: 1094-1097 (2012)
Featured in Schuldt, A.: Small molecule time management. Nat. Rev. Mol. Cell Biol. 13: 479 (2012)
Featured in Ray, L.B.: Modulating the Clock. Sci. Signal. 5: ec235 (2012)
Featured in Gordon, E.J.: A compound that stops the clock. ACS Chem. Biol. 7: 1308 (2012)

5)

Lee, J.W. ^#, Hirota, T.^#, Peters, E.C., Garcia, M., Gonzalez, R., Cho, C.Y., Wu, X., Schultz, P.G. ^*, and Kay, S.A. ^*: A small molecule modulates circadian rhythms through phosphorylation of the period protein.
Angew. Chem. Int. Ed., 50: 10608-10611 (2011)
Featured in Soares, J.A.: Altering time. ACS Chem. Biol. 6: 1145 (2011)

4)

Hirota, T., Lee, J.W., Lewis, W.G., Zhang, E.E., Breton, G., Liu, X., Garcia, M., Peters, E.C., Etchegaray, J.P., Traver, D., Schultz, P.G., and Kay, S.A. ^*: High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.
PLoS Biol., 8: e1000559 (2010)

3)

Zhang, E.E. ^#, Liu, Y. ^#, Dentin, R., Pongsawakul, P.Y., Liu, A.C., Hirota, T., Nusinow, D.A., Sun, X., Landais, S., Kodama, Y., Brenner, D.A., Montminy, M. ^*, and Kay, S.A. ^*: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis.
Nat. Med., 16: 1152-1156 (2010)
Featured in Bass, J.: High glucose, no cry. Nat. Med. 16: 1074-1076 (2010)
Selected by Faculty of 1000 Biology

2)

Zhang, E.E. ^#, Liu, A.C. ^#, Hirota, T.^#, Miraglia, L.J., Welch, G., Pongsawakul, P.Y., Liu, X., Atwood, A., Huss, J.W. 3rd, Janes, J., Su, A.I., Hogenesch, J.B. ^*, and Kay, S.A. ^*: A genome-wide RNAi screen for modifiers of the circadian clock in human cells.
Cell, 139: 199-210 (2009)
Selected by Faculty of 1000 Biology

1)

Hirota, T., Lewis, W.G., Liu, A.C., Lee, J.W., Schultz, P.G., and Kay, S.A. ^*: A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β.
Proc. Natl. Acad. Sci. USA, 105: 20746-20751 (2008)

6)

Hatori, M. and Hirota, T.^*: Cell-based phenotypic screens to discover circadian clock modulating compounds.
Methods. Mol. Biol., 2482: 95-104 (2022)
Special issue "Circadian Regulation" (Solanas, G. and Welz, P.S. eds.)

5)

Miller, S. and Hirota, T.^*: Structural and chemical biology approaches reveal isoform-selective mechanisms of ligand interactions in mammalian Cryptochromes.
Front Physiol., 13: 837280 (2022)
Special issue "De - Crypting Cryptochromes: Electromagnetic Field Sensors and Clockwork for Quantum Biology and Medicine" (Ahmad, M. and Crane, B.R. eds.)

4)

Amaike, K., Oshima, T., Skoulding, N.S., Toyama, Y., Hirota, T.^*, and Itami, K. ^*: Small molecules modulating mammalian biological clocks: Exciting new opportunities for synthetic chemistry.
Chem., 6: 2186-2198 (2020)

3)

Miller, S. and Hirota, T.^*: Pharmacological interventions to circadian clocks and their molecular bases.
J. Mol. Biol., 432: 3498-3514 (2020)
Special issue "Circadian Regulation: from Molecules to Physiology" (Wolf, E. and Kramer, A. eds.)

2)

Hirota, T. and Kay, S.A. ^*: Identification of small-molecule modulators of the circadian clock.
Methods Enzymol., 551: 267-282 (2015)
Special issue "Circadian Rhythms and Biological Clocks" (Sehgal, A. ed.)

1)

Hirota, T. and Kay, S.A. ^*: High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms.
Chem. Biol., 16: 921-927 (2015)

1)

Hirota, T., Hatori, M., and Panda, S. eds.: Circadian Clocks.
Neuromethods series, volume 186, 429 pages, Springer Nature (2022)

6)

松田 智宏、廣田 毅: 概日時計の分子機構をケミカルバイオロジーで紐解く.
化学と生物, 60, 212-214 (2022)

5)

Miller, S. and Hirota, T.: Structural insights into isoform-selective regulators of mammalian Cryptochromes.
SPring-8 SACLA Research Frontiers 2020, 22-23 (2021)

4)

飯田 夢惟、廣田 毅: 概日時計を標的とした化合物と創薬の最前線.
Medical Science Digest, 47:417-419 (2021)

3)

廣田 毅、松田 智宏: 体内時計のケミカルバイオロジー研究と創薬の可能性.
MedChem News, 31:62-67 (2021)

2)

松田 智宏、廣田 毅: 化合物を使って体内時計を操る―概日リズム研究の最前線.
化学, 75:66-67 (2020)

1)

羽鳥 恵、廣田 毅: 時計遺伝子から考える脳機能と食.
FOOD Style21, 23:80-83 (2019)