Publications
Articles
21) |
Miller, S., Kesherwani, M., Chan, P., Nagai, Y., Yagi, M., Cope, J., Tama, F., Kay, S.A. *, and Hirota, T.*: CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. |
20) |
Yagi, M. #, Miller, S. #, Nagai, Y. #, Inuki, S., Sato, A., and Hirota, T.*: A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. |
19) |
Iida, M., Nakane, Y., Yoshimura, T. *, and Hirota, T.*: Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish. |
18) |
Miller, S. #, Srivastava, A. #, Nagai, Y., Aikawa, Y., Tama, F., and Hirota, T.*: Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. |
17) |
Kolarski, D., Vinyals, C.M. #, Sugiyama, A. #, Srivastava, A., Ono, D., Nagai, Y., Iida, M., Itami, K., Tama, F., Szymanski, W. *, Hirota, T.*, and Feringa, B.L. *: Reversible modulation of circadian time with chronophotopharmacology. |
16) |
Kolarski, D. #, Miller, S. #, Oshima, T. #, Nagai, Y., Aoki, Y., Kobauri, P., Srivastava, A., Sugiyama, A., Amaike, K., Sato, A., Tama, F., Szymanski, W., Feringa, B.L. *, Itami, K. *, Hirota, T.*: Photopharmacological manipulation of mammalian CRY1 for regulation of the circadian clock. |
15) |
Miller, S. #, Aikawa, Y. #, Sugiyama, A., Nagai, Y., Hara, A., Oshima, T., Amaike, K., Kay, S.A., Itami, K., and Hirota, T.*: An isoform-selective modulator of Cryptochrome 1 regulates circadian rhythms in mammals. |
14) |
Miller, S. #, Son, Y.L. #, Aikawa, Y. #, Makino, E., Nagai, Y., Srivastava, A., Oshima, T., Sugiyama, A., Hara, A., Abe, K., Hirata, K., Oishi, S., Hagihara, S., Sato, A., Tama, F., Itami, K., Kay, S.A., Hatori, M. *, and Hirota, T.*: Isoform-selective regulation of mammalian cryptochromes. |
13) |
Kolarski, D., Sugiyama, A., Breton, G., Rakers, C., Ono, D., Schulte, A., Tama, F., Itami, K., Szymanski, W., Hirota, T.*, and Feringa, B.L. *: Controlling the circadian clock with high temporal resolution through photodosing. |
12) |
Lee, J.W. #,*, Hirota, T.#,*, Ono, D., Honma, S., Honma, K.I., Park, K., and Kay, S.A.: Chemical control of mammalian circadian behavior through dual inhibition of casein kinase Iα and δ. |
11) |
Oshima, T. #, Niwa, Y. #, Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y., Yagita, K., Ikeda, M., Kinoshita, T., Kay, S.A., Itami, K.*, and Hirota, T.*:Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. |
10) |
Qu, M., Duffy, T., Hirota, T., and Kay, S.A. *: Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. |
9) |
Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L., Lamia, K., Liu, S., Atkins, A.R., Banayo, E., Liddle, C., Yu, R.T., Yates III, J.R., Kay, S.A., Downes, M. *, and Evans, R.M. *: Circadian amplitude regulation via FBXW7-targeted REV-ERBα degradation. |
8) |
Lee, J.W.#, Hirota, T.#,*, Kumar, A. #,*, Kim, N.J., Irle, S., and Kay, S.A. *: Development of small molecule Cryptochrome stabilizer derivatives as modulators of the circadian clock. |
7) |
St. John, P.C., Hirota, T., Kay, S.A. *, and Doyle, F.J. 3rd*: Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. |
6) |
Hirota, T., Lee, J.W., St. John, P.C., Sawa, M., Iwaisako, K., Noguchi, T., Pongsawakul, P.Y., Sonntag, T., Welsh, D.K., Brenner, D.A., Doyle, F.J. 3rd, Schultz, P.G. *, and Kay, S.A. *: Identification of small molecule activators of cryptochrome. |
5) |
Lee, J.W. #, Hirota, T.#, Peters, E.C., Garcia, M., Gonzalez, R., Cho, C.Y., Wu, X., Schultz, P.G. *, and Kay, S.A. *: A small molecule modulates circadian rhythms through phosphorylation of the period protein. |
4) |
Hirota, T., Lee, J.W., Lewis, W.G., Zhang, E.E., Breton, G., Liu, X., Garcia, M., Peters, E.C., Etchegaray, J.P., Traver, D., Schultz, P.G., and Kay, S.A. *: High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. |
3) |
Zhang, E.E. #, Liu, Y. #, Dentin, R., Pongsawakul, P.Y., Liu, A.C., Hirota, T., Nusinow, D.A., Sun, X., Landais, S., Kodama, Y., Brenner, D.A., Montminy, M. *, and Kay, S.A. *: Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. |
2) |
Zhang, E.E. #, Liu, A.C. #, Hirota, T.#, Miraglia, L.J., Welch, G., Pongsawakul, P.Y., Liu, X., Atwood, A., Huss, J.W. 3rd, Janes, J., Su, A.I., Hogenesch, J.B. *, and Kay, S.A. *: A genome-wide RNAi screen for modifiers of the circadian clock in human cells. |
1) |
Hirota, T., Lewis, W.G., Liu, A.C., Lee, J.W., Schultz, P.G., and Kay, S.A. *: A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β. |
Reviews
6) |
Hatori, M. and Hirota, T.*: Cell-based phenotypic screens to discover circadian clock modulating compounds. |
5) |
Miller, S. and Hirota, T.*: Structural and chemical biology approaches reveal isoform-selective mechanisms of ligand interactions in mammalian Cryptochromes. |
4) |
Amaike, K., Oshima, T., Skoulding, N.S., Toyama, Y., Hirota, T.*, and Itami, K. *: Small molecules modulating mammalian biological clocks: Exciting new opportunities for synthetic chemistry. |
3) |
Miller, S. and Hirota, T.*: Pharmacological interventions to circadian clocks and their molecular bases. |
2) |
Hirota, T. and Kay, S.A. *: Identification of small-molecule modulators of the circadian clock. |
1) |
Hirota, T. and Kay, S.A. *: High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. |
Edited books
1) |
Hirota, T., Hatori, M., and Panda, S. eds.: Circadian Clocks. |
Book chapters
6) |
松田 智宏、廣田 毅: 概日時計の分子機構をケミカルバイオロジーで紐解く. |
5) |
Miller, S. and Hirota, T.: Structural insights into isoform-selective regulators of mammalian Cryptochromes. |
4) |
飯田 夢惟、廣田 毅: 概日時計を標的とした化合物と創薬の最前線. |
3) |
廣田 毅、松田 智宏: 体内時計のケミカルバイオロジー研究と創薬の可能性. |
2) |
松田 智宏、廣田 毅: 化合物を使って体内時計を操る―概日リズム研究の最前線. |
1) |
羽鳥 恵、廣田 毅: 時計遺伝子から考える脳機能と食. |
(#, co-first author; *, correspondence)