Nagoya University

Graduate Program of Transformative Chem-Bio Research

EVENTS

GTR-RCMS Seminar

Presenter:Prof. Hao XU (Brandeis University, Boston USA)
   https://www.brandeis.edu/chemistry/faculty/xu-hao.html

Date/time:2021/3/26 (Fri) 9:00-10:30 AM (Japan time) *Online lecture
Title : Searching for New Reactivity: Iron-Catalyzed Selective Nitrogen Atom Transfer

Language : English

Abstract : Numerous pharmaceuticals contain at least one nitrogen atom and many of those nitrogen
atoms are directly attached to stereogenic centers.
Therefore, synthetic methods that incorporate
selective nitrogen atom transfer to readily available hydrocarbons are important tools for the
synthesis of these valuable molecules. While methods for selective olefin aziridination and direct
C-H amination are well-established, methods for direct functionalization of olefins with a nitrogen
atom and a range of heteroatom-based functional groups are less explored yet critically important to
organic synthesis and its applications to the biomedical sciences.
This lecture is about the discovery and development of a range of iron-catalyzed nitrogen atom
transfer reactions with an emphasis on stereoselective olefin aminohydroxylation, aminofluorination,
and diazidation-diamination reactions. This lecture will also discuss mechanistic studies that have
enabled the gram-scale Tamiflu® synthesis and the discovery of highly cis-selective glycal
amidoglycosylation.

Please make a registration here , by Mar24th.

Contact: Susumu SAITO
saito.susumu<at>f.mbox.nagoya-u.ac.jp (<at>→@)