GTR Seminar
Date: June 13 (Fri.) 2025,16:30-18:00
Venue: 143 Lecture Room, Eng. Building No. 1
Speaker: Prof.Billy Wai-Lung Ng（School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong）
Title:Targeted Protein O-GlcNAcylation in Living Cells
Abstract:Protein O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) plays a crucial role in regulating essential cellular processes. The disruption of O-GlcNAcylation homeostasis has been linked to various human diseases, including cancer, diabetes, and neurodegeneration. However, there are limited chemical tools for protein- and site-specific O-GlcNAc modification, rendering the precise study of O-GlcNAcylation challenging. To address this, we have developed heterobifunctional small molecules, named O-GlcNAcylation TArgeting Chimeras (OGTACs), which enable protein-specific O-GlcNAcylation in living cells. OGTACs promote O-GlcNAcylation of proteins such as p53, BRD4, CK2α, and EZH2 in cellulo by recruiting FKBP12F36V-fused O-GlcNAc transferase (OGT), with temporal, magnitude, and reversible control. Overall, OGTACs represent a promising approach for inducing protein-specific O-GlcNAcylation, thus enabling functional dissection and offering new directions for O-GlcNAc-targeting therapeutic development.
Contact: Shigeki Kiyounaka ✉ kiyonaka<at>chembio.nagoya-u.ac.jp （<at>→@）
★GTR international students only
These seminars are "GTR Lecture series on multidisciplinary problems (1pt.)".
Enroll in gtr e-portfolio (Dead line: June 11)．Grades will be judged by report. Report submission from TACT by June 27th.