GTR Seminar
Date: June 19 (Tue.) 2025,15:00-17:00
Venue: Lecture Hall, 2F, Noyori Materials Science Laboratory
Speaker: Dr. Ruyi Zhu (Department of Chemistry / NUS, Singapore)
Title:New Advances in DNA Catalysis and RNA Modification
Language: English
Abstract: DNA is an underexplored scaffold for asymmetric catalysis. Its structure can be programmed to adopt enzyme-like 3-D structure or even architectures resembling MOF/COF. In this talk, I will discuss how we harness ubiquitous phosphates for ion-pairing DNA catalysis and how the helical structure of DNA, in conjunction with a bimetallic center, facilitates a new mode of sterecontrol. This bimetallic DNA catalyst enables the construction of multiple contiguous stereogenic centers with switchable enantioselectivity as well as switchable chemoselectivity.
In the latter part of the talk, I will introduce a "install-deliver-release" strategy for RNA delivery and a site-selective RNA modification method using catalysis. We leverage post-synthetic RNA acylation and disulfide exchange chemistry for RNA delivery and conjugation. I will talk about thiol-mediated RNA delivery via non-endocytosis pathway and GalNAc-mediated cell-selective RNA delivery.
I will end my presentation talking about a universal site-selective RNA modification approach and its applications.
Contact: Hiroshi Abe (Ext. 2490)
E-mail: h-abe<at>chem.nagoya-u.ac.jp <at>→@
★GTR international students only
These seminars are "GTR Lecture series on multidisciplinary problems (1pt.)".
Enroll in gtr e-portfolio (Dead line: June 16)．Grades will be judged by report. Report submission from TACT by July 3.