GTR Seminar
Date: June 15 (Mon), 2026, 16:00-17:00
Venue: ITbM 1F Lecture Room
Speaker: Prof. Dr. Grégory Vert (Professor/Research Director, Plant Science Research Laboratory CNRS/University of Toulouse)
Title: Ubiquitin-mediated regulation of cell signaling and endocytosis in plants
Language: English
Contact: Akira Yoshinari ex:6477 ✉yoshinari.akira.t2<at>f.mail.nagoya-u.ac.jp (<at>→@)
Abstract
Ubiquitination is a post-translational modification essential for the regulation of eukaryotic proteins, having an impact on protein fate, function, localization or activity. What originally appeared to be a simple system to regulate protein turnover by the 26S proteasome is now known to be the most intricate regulatory process cells have evolved. Ubiquitin can be arranged in countless chain assemblies, and here I will present our work deconstructing lysine(K)63-linked polyubiquitin chains, highlighting its major contribution in the control of plasma membrane protein dynamics and endocytosis. In particular, I will highlight how K63 polyubiquitination has been coopted to regulate plant metal nutrition through a complex interplay of ubiquitin modifications and E3 ubiquitin ligases, and showcase how different ubiquitin-like protein modifications together allow the fine tuning of steroid hormone signaling in plants.
Representative publications relevant to the talk
1) Dellesalle, C., Montiel-Jorda, A., Aiba, R., Spielmann, J., Neveu, J., Fujita, S. and Vert, G. (2026). Arabidopsis Microtubule-BRI1 Associated Proteins negatively regulate hypocotyl elongation by controlling brassinosteroid-dependent cortical microtubule reorientation. Plant Communications 7(2):101637.
2) Saeed, B., Deligne, F., Brillada, C., Dünser, K., Ditengou, F.A., Turek, I., Allahham, A., Grujic, N., Dagdas, Y., Ott, T., Kleine-Vehn, J., Vert, G., and Trujillo, M. (2023). K63-linked ubiquitin chains are a global signal for endocytosis and contribute to selective autophagy in plants. Current Biology 2023 33:1337-1345.
3) Naranjo-Arcos, M., Srivastava, M., Deligne, F., Bhagat, P.K., Mansi, M., Sadanandom, A., and Vert, G. (2023). SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature. PNAS 120(4):e2217255120.
4) Romero-Barrios, N. Monachello, D., Dolde, U., Wong, A., San Clemente, H., Cayrel, A., Johnson, A., Lurin, C., and Vert, G. (2020). Advanced cataloging of K63 polyubiquitin networks by genomic, interactome and sensor-based proteomic analyses. Plant Cell 32, 123-138.
5) Dubeaux, G., Neveu, J., Zelazny, E., and Vert, G. (2018). Metal sensing by the IRT1 transceptor orchestrates its degradation by differential ubiquitination, and responses to metal stress. Molecular Cell 69, 953-964.
6) Martins, S., Montiel, A., Cayrel, A., Huguet, S., Paysant-Leroux, C., Ljung, K., and Vert G. (2017). Brassinosteroid signaling-dependent root responses to prolonged elevated ambient temperature involves BRI1 ubiquitination. Nature Communications 8, 309.
7) Martins, S., Dohmann, E., Cayrel, A., Johnson, A., Fischer, W., Pojer, F., Satiat-Jeunemaitre, B., Jaillais, Y., Chory, J., Geldner, N., and Vert, G. (2015). Dual role of K63 polyubiquitination in the endocytosis of the BRI1 plant steroid hormone receptor. Nature Communications 6, 6151.