GTR Seminar
下記内容でGTRセミナーを開催いたしますので、ぜひお越しください。
日時：6月13日（金）16:30-18:00
場所：名古屋大学東山キャンパス 工学部１号館１４３講義室
演者：Prof.Billy Wai-Lung Ng（School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong）
タイトル：Targeted Protein O-GlcNAcylation in Living Cells
要旨：Protein O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) plays a crucial role in regulating essential cellular processes. The disruption of O-GlcNAcylation homeostasis has been linked to various human diseases, including cancer, diabetes, and neurodegeneration. However, there are limited chemical tools for protein- and site-specific O-GlcNAc modification, rendering the precise study of O-GlcNAcylation challenging. To address this, we have developed heterobifunctional small molecules, named O-GlcNAcylation TArgeting Chimeras (OGTACs), which enable protein-specific O-GlcNAcylation in living cells. OGTACs promote O-GlcNAcylation of proteins such as p53, BRD4, CK2α, and EZH2 in cellulo by recruiting FKBP12F36V-fused O-GlcNAc transferase (OGT), with temporal, magnitude, and reversible control. Overall, OGTACs represent a promising approach for inducing protein-specific O-GlcNAcylation, thus enabling functional dissection and offering new directions for O-GlcNAc-targeting therapeutic development.
問い合わせ先：清中 茂樹 kiyonaka<at>chembio.nagoya-u.ac.jp(<at>→@に変換）
★このセミナーは外国人GTR学生向けGTRシリーズ講義です。それぞれの講義についてレポートを提出し合格した外国人GTR生には、シリーズ講義1ポイントが
付与されます。レポートはTACTから提出いただきます。受講を希望する場合はGTR e-ポートフォリオにも登録してください。
登録締め切り：6月11日