GTR Seminar
下記内容でGTRセミナーを開催いたしますので、ぜひお越しください。
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日時：6月19日（木）15:00-17:00
場所：名古屋大学東山キャンパス 野依記念物質科学研究館、2階、講演室
演者：Ruyi Zhu (Department of Chemistry / NUS, Singapore)
タイトル：New Strategies for Post-Synthetic RNA Modifications
要旨：RNA modifications play a crucial role in RNA biology and hold significant promise for therapeutic applications. However, key challenges remain in the field of RNA biomedical research, including RNA stabilization, targeted delivery, and site-selective modification of long RNA. Our lab is focused on developing innovative chemical strategies to address these hurdles. In this talk, I will present an "install-deliver-release" approach for RNA delivery, along with a catalytic method for site-selective RNA modification. Our work utilizes post-synthetic RNA acylation and disulfide exchange chemistry to enable efficient RNA conjugation and delivery. I will discuss thiol-mediated RNA delivery through a non-endocytic pathway, as well as GalNAc-mediated strategies for cell-selective RNA delivery. Finally, I will introduce a programmable and broadly applicable platform for site-selective RNA modification and highlight its potential applications.
問い合わせ先:阿部 洋（内線2490）✉ h-abe<at>chem.nagoya-u.ac.jp <at>→@に変換
★このセミナーは外国人GTR学生向けGTRシリーズ講義です。それぞれの講義についてレポートを提出し合格した外国人GTR生には、シリーズ講義1ポイントが
付与されます。レポートはTACTから提出いただきます。受講を希望する場合はGTR e-ポートフォリオにも登録してください。
登録締め切り：6月16日