GTR ORGANIC SEMINAR
この度、ACP Lectureship 2025を受賞された香港中文大学の新進気鋭な若手研究者Hairong Lyu先生を招聘し、10 月 20 日(火) 16:30からVBL 3F、ベンチャーホールにて講演会を開催します。この機会に是非ご参加ください。
Lyu先生は新規な中性 sp²-sp³ ジボロン試薬を合成し、ボリル化剤およびホウ素シントン前駆体としての性質に着目し、これらの試薬が官能基化に有用なツールとなり得ることを実証しました。さらに、電気化学的に駆動される Matteson 型ホモロゲーションを報告しました。この手法は、Matteson 反応の発見以来長年にわたって存在してきた課題に対する、概念実証（proof-of-concept）となる解決策を提供するものです。
Abstract
Organoboron compounds have found broad applications in synthetic chemistry, biomedicine, and materials science. The synthesis of organoborons and their downstream transformations, which continue to attract significant research interest, rely on the development of new boron reagents and methodologies. However, despite considerable advancements, the range of well-established and widely utilized boron reagents remains limited, thereby constraining the diversity of reaction modes available from these reagents. Recently, we synthesized a series of new neutral sp²-sp³ diboron reagents and explored their properties as borylation agents and precursors for boron synthons. We also investigated their applications in synthetic chemistry, demonstrating their potential as valuable tools for the synthesis and functionalization of organoboron compounds. Furthermore, we reported an electrochemically driven Matteson-type homologation, providing a proof-of-concept solution to the longstanding challenges associated with this reaction since its discovery.
Biography
Dr. Hairong Lyu obtained her bachelor's degree from Nankai University in 2014. After completing her PhD at the Chinese University of Hong Kong under the supervision of Prof. Zuowei Xie, she moved to the University of Chicago, working as a postdoctoral scholar with Prof. Guangbin Dong. In 2022, she joined The Chinese University of Hong Kong as an assistant professor with the Vice-Chancellor Early Career Professorship Scheme. In 2024, she received the Croucher Tak Wah Mak Innovation Awards. The current research focus in her team includes the development and applications of new reagents and synthetic methodologies.
Representative Publications:
1) Tao, H.; Huang, Z.; Lyu, H.* "Enantioenriched Alkylboron Synthesis Via a Chiral Diborylalkane Platform" J. Am. Chem. Soc. 2026, doi.org/10.1021/jacs.6c13223.
2) Cheung, T. L.; Li, Y.; Zhang, P.; Yang, Z.; Quan, Y.*; Lyu, H.* "Electrochemical Defluorinative Matteson-Type Homologation" Nature 2026, 650, 621-628.
3) Sun, W.; Zhang, P.; Lyu, H.* "Mild Generation of Highly Nucleophilic N-Heterocyclic Carbene Boryl Anion from Neutral sp2
-sp3 Diboron Reagents and Its Applications in Nucleophilic Borylation" Angew. Chem. Int. Ed. 2026, 65, e7517492.
お問い合わせ：Muhammet Uyanik &石原一彰（内線 3206，3331）
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登録締め切り：10月18日