RESEARCHERID

Jeffrey W. Bode

Principal Investigator, Professor, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland

Website：http://www.bode.ethz.ch/
E-mail：bode[at]org.chem.ethz.ch　(Please replace [at] with @ when sending an email.)

Organic synthesis, carbene-catalysis, protein synthesis, bioconjugation, oligomerization
Bode is a gifted young rising star in synthetic chemistry. The work of Bode is directed towards the chemical synthesis of molecules and conjugates that are currently outside the reach of conventional synthetic methods. He is developing new chemical reactions and catalysts for making molecules of biological importance such as proteins, glycopeptides, sequence and length-controlled polymers, and covalent conjugates of these large structures. Recently, he developed a novel method for the ligation of unprotected protein segments, producing synthetic proteins very efficiently. He is also known as one of the pioneers of an entirely new branch of catalytic asymmetric synthesis, commonly known as "chiral N-heterocyclic carbene (NHC) catalysis". His catalysts will be applied in the development of molecules that selectively induce plant growth and molecules that can overcome species barrier. In addition, collaborating with the group of Ooi, he will also be involved in the development of small-molecule catalysts that can activate and transform bio-molecules in vivo.

Profile


1996B.S.; Trinity University, Texas, USA (Chemistry),
B.A.; Trinity University, Texas, USA (Philosophy)
1998Candidacy for Ph.D; California Institute of Technology, Pasadena, USA
2001Dok. Nat. Sci.; ETH Zürich, Switzerland
2001-2003JSPS Postdoctoral Fellow; Tokyo Institute of Technology
2003-2007Assistant Professor; University of California, Santa Barbara, USA
2007-2009Associate Professor; University of Pennsylvania, USA
2009Full Professor; University of Pennsylvania, USA
2010-presentFull Professor; ETH–Zürich, Switzerland
2013-presentVisiting Professor; WPI-ITbM, Nagoya University

Research Highlights

Press

Selected Awards and Honors

2013 Fellow of the Royal Society of Chemistry, UK
2012 ERC Starting Grant
2011 Elias J. Corey Award (ACS)
2010 Hirata Gold Medal
2008 Arthur C. Cope Scholar Award (ACS)

Selected Publications

  • Rohrbacher, F.; Deniau, G.; Luther, A.; Bode, J. W. Chem. Sci. 2015, 6, 4889-4896. Spontaneous Head-to-Tail Cyclization of Unprotected Linear Peptides with the KAHA Ligation. DOI: 10.1039/c5sc01774b
  • Murar, C. E.; Thuaud, F.; Bode, J. W. J. Am. Chem. Soc. 2014, 136, 18140-18148. KAHA Ligations that form Aspartyl Aldehyde Residues as Synthetic Handles for Protein Modification and Purification. DOI: 10.1021/ja511231f
  • Wucherpfennig, T. G.; Pattabiraman, V. R.; Limberg, F. R. P.; Ruiz-Rodríguez, J.; Bode, J. W. Angew. Chem. Int. Ed. 2014, 53, 12248-12252. Traceless Preparation of C-Terminal α-Ketoacids for Chemical Protein Synthesis by α-Ketoacid-Hydroxylamine Ligation: Synthesis of SUMO2/3. DOI: 10.1002/anie.201407014
  • Huang, Y. L.; Bode, J. W. Nature Chem. 2014, 6, 877-884. Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents. DOI: 10.1038/nchem.2048
  • Noda, H; Erős, G; Bode, J. W. J. Am. Chem. Soc. 2014, 136, 5611-5614. Rapid Ligations with Equimolar Reactants in Water with the Potassium Acyltrifluoroborate (KAT) Amide-Formation. DOI: 10.1021/ja5018442