Takashi Yoshimura
Director of ITbM, Principal Investigator, Professor
Website:https://www.agr.nagoya-u.ac.jp/~aphysiol/en_index/
E-mail:takashiy[at]agr.nagoya-u.ac.jp (Please replace [at] with @ when sending an email.)
Biological Clocks, Systems Biology, Animal Reproduction, Food and Health
In addition to serving as the Director of ITbM, Yoshimura leads an independent research group as a Principal Investigator. His research has focused on elucidating the mechanisms underlying circadian clocks and seasonal time measurement in vertebrates. The originality of Yoshimura’s work lies in the application of systems biology approaches to unique animal species with distinctive phenotypes, such as quail and hamsters, to uncover the sophisticated adaptive strategies that organisms have evolved for survival. Using this approach, his group successfully identified the “springtime hormone” that enables animals to detect the arrival of spring and elucidated the underlying signaling pathway. Furthermore, his group has identified molecules involved in the regulation of biological clocks and identified risk factors associated with seasonal disorders, establishing this research area as one of ITbM’s flagship projects. Through close collaboration with chemists and theoreticians, Yoshimura is also advancing the development of functional molecules and technologies that contribute to sustainable food production and human health.
Profile
| 1993 | B.S.; Nagoya University (Animal Physiology) |
| 1995 | M.S.; Nagoya University (Animal Physiology) |
| 1996 | Dr. Agr.; Nagoya University (Animal Physiology) |
| 1995-1996 | JSPS Research Fellow (DC) |
| 1996-1999 | Assistant Professor; School of Agricultural Science, Nagoya University |
| 1999-2005 | Assistant Professor; Graduate School of Bioagricultural Science, Nagoya University |
| 2005-2008 | Associate Professor; Graduate School of Bioagricultural Science, Nagoya University |
| 2008-present | Professor; Graduate School of Bioagricultural Science, Nagoya University |
| 2013-present | Professor; WPI-ITbM, Nagoya University |
| 2013-2019 | National Institute for Basic Biology, Visiting Professor |
| 2022-present | Director of ITbM ; WPI-ITbM, Nagoya University |
Research Highlights
- Seasonal changes affect alcohol tolerance and your waistline(2025.04.30)
- Controlling lipid levels with less side effects possible with new drug(2024.08.06)
- STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179(2024.05.14)
- A transcriptional program underlying the circannual rhythms of gonadal development in medaka(2023.12.19)
- A pheromone that explains why puffer fish spawn on beaches under moonlight(2022.10.28)
Selected Awards and Honors
| 2026 | Naito Foundation Merit Award |
| 2025 | Chunichi Cultural Award |
| 2024 | Aschoff's Rule Prize |
| 2021 | Kihara Memorial Yokohama Foundation |
| 2020 | Aschoff and Honma Prize for Biological Rhythm Research |
| 2019 | Axelrod Lectureship Award |
| 2015 | Incentive Award, The Japan Society for Comparative Endocrinology |
| 2015 | Van Meter Award, ATA |
| 2010 | Fellow of the Society for Biology, UK |
| 2010 | Hoffenberg International Medal from the Society for Endocrinology, UK |
| 2009 | JSPS Prize |
| 2009 | Japanese Society of Animal Science Prize |
Selected Publications
- Chen, J.; Okimura, K.; Ren, L.; Nakane, Y.; Nakayama, T.; Chen, Y.; Fukawa, K.; Sugiyama, S.; Natsume, T.; Suda-Hashimoto, N.; Morimoto, M.; Miyabe-Nishiwaki, T.; Oishi, T.; Katada, Y.; Zhang, M.; Kobayashi, K.; Matsumoto, S.; Yamaguchi, T.; Guh, Y.J.; Takahashi, I.; Nishiwaki-Ohkawa, T.; Sato, D.; Murata, Y.; Sumiyama, K.; Nagano, A.J.; Imai, H.; Yoshimura, T. Nat. Commun. 2025, 16, 3906. Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases. DOI: 10.1038/s41467-025-57994-1
- Nambo, M.; Nishiwaki-Ohkawa, T.; Ito, A.; Ariki, Z.T.; Ito, Y.; Kato, Y.; Yar, M.; Yim, J.C.H.; Kim, E.; Sharkey, E.; Kano, K.; Mishiro-Sato, E.; Okimura, K.; Maruyama, M.; Ota, W.; Furukawa, Y.; Nakayama, T.; Kobayashi, M.; Horio, F.; Sato, A.; Crudden, C.M.; Yoshimura, T. Commun. Med. 2024, 4, 152. Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261. DOI: 10.1038/s43856-024-00574-z
- Nakayama, T.; Tanikawa, M.; Okushi, Y.; Itoh, T.; Shimmura, T.; Maruyama, M.; Yamaguchi, T.; Matsumiya, A.; Shinomiya, A.; Guh, Y.J.; Chen, J.; Naruse, K.; Kudoh, H.; Kondo, Y.; Naoki, H.; Aoki, K.; Nagano, A.J.; Yoshimura, T. Proc. Natl. Acad. Sci. USA. 2023, 120, e2313514120. A transcriptional program underlying the circannual rhythms of gonadal development in medaka. DOI: 10.1073/pnas.2313514120
- Chen, J.; Katada, Y.; Okimura, K.; Yamaguchi, T.; Guh, Y.J.; Nakayama, T.; Maruyama, M.; Furukawa, Y.; Nakane, Y.; Yamamoto, N.; Sato, Y.; Ando, H.; Sugimura, A.; Tabata, K.; Sato, A.; Yoshimura, T. Curr. Biol. 2022, 32, 1-9. Prostaglandin E2 synchronizes lunar-regulated beach-spawning in grass puffer. DOI: 10.1016/j.cub.2022.09.062
- Nakayama, T.; Okimura, K.; Shen, J.; Guh, Y.J.; Tamai, T.K.; Shimada, A.; Minou, S.;
Okushi, Y.; Shimmura, T.; Furukawa, Y.; Kadofusa, N.; Sato, A.; Nishimura, T.; Tanaka, M.; Nakayama, K.; Shiina, N.; Yamamoto, N.; Loudon, A.S.; Nishiwaki-Ohkawa, T.; Shinomiya, A.; Nabeshima, T.; Nakane, Y.; Yoshimura, T. Proc. Natl. Acad. Sci. USA. 2020, 117, 9594-9603. Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior. DOI: 10.1073/pnas.2000278117
- Members
- Yoshimura Group
- Yamaguchi Group
- Bode Group
- Crudden Group
- Frommer Group
- Yagi Group
- Kamikouchi Group
- Hirota Group (collaborating with Kay)
- Kinoshita Group
- Ooi Group
- Tama Group
- Shimotohno Group (collaborating with Torii)
- Tsuchiya Group
- Yanai Group
- Laohavisit Group
- Mizuta Group
- Phung Group
- Kurihara Group
- Molecular Structure Center
- Live Imaging Center
- Chemical Library Center
- Peptide Protein Center
- Administrative Department
- Affiliated Researchers
