Steve Kay
Collaborating Researcher, Professor, University of Southern California
Website:http://www.itbm.nagoya-u.ac.jp/en/kay-hirota_group/
E-mail:dean[at]dornsife.usc.edu (Please replace [at] with @ when sending an email.)
Biological clock, systems biology
By using the resources of clock modifying compounds and genes in combination with state-of-the-art technologies at ITbM, the Kay-Hirota group aims to discover "transformative bio-molecules" that will revolutionize clock research and ultimately benefit human health.
A unique combination of molecular, genetic, genomic, biochemical, and chemical biology approaches will allow us to reveal key regulatory processes of the circadian clock and define molecular links between the clock and rhythmic regulation of physiology and behavior.
Proof-of-concept chemical probes will provide useful tools to control clock function in a conditional manner and also act as starting points for developing therapeutics for circadian clock-related disorders.
Profile
1981 | B.Sc.; University of Bristol, UK (Biochemistry) |
1984 | Ph.D.; University of Bristol, UK (Biochemistry) |
1985-1989 | Postdoctoral Fellow; The Rockefeller University, USA |
1989-1991 | Assistant Professor; The Rockefeller University, USA |
1992-1995 | Assistant Professor; University of Virginia, USA |
1995-1996 | Associate Professor (tenured); University of Virginia, USA, Associate Professor; University of Virginia Medical School, USA |
1996-1998 | Associate Professor; The Scripps Research Institute, USA |
1999-2004 | Director; Discovery Research, Genomics Institute of the Novartis Research Foundation, USA |
2002-2003 | Founder; Chief Technology Officer and Senior Vice President, Phenomix Corporation, USA |
2000-present | Adjunct Professor; University of California, San Diego, USA |
2001-2007 | Director; Institute for Childhood and Neglected Diseases, The Scripps Research Institute, USA |
1998-2007 | Professor; The Scripps Research Institute, USA |
2004-2007 | Chairman; Scripps Florida Steering Committee, USA |
2005-2007 | Chairman; The Scripps Research Institute, USA |
2007-2012 | Professor; University of California, San Diego, USA |
2007-2012 | Richard C. Atkinson Chair in the Biological Sciences; USA |
2007-2012 | Dean; Division of Biological Sciences, University of California, San Diego, USA |
2009-present | Adjunct Professor; Salk Institute for Biological Studies, USA |
2012-present | Professor; University of Southern California, USA |
2012-2015 | Dean; Dornsife College of Letters, Arts and Sciences, University of Southern California, USA |
2014-present | Overseas Principal Investigator; WPI-ITbM, Nagoya University |
2015-2016 | President; The Scripps Research Institute, USA |
2016-present | Provost Professor of Neurology, Biomedical Engineering and Biological Sciences, Director of Convergent Bioscience; University of Southern California, USA |
Selected Awards and Honors
2018 | Clarivate Analytics Highly Cited Researcher |
2017 | Clarivate Analytics Highly Cited Researcher |
2015 | Thomson Reuters "Most Influential Scientific Minds" |
2014 | Thomson Reuters Highly Cited Researcher |
2014 | Honorary D.Sc. degree, University of Bristol, UK |
2011 | Martin Gibbs Medal, American Society of Plant Biology |
2010 | UCSD Chancellor's Associates Faculty Award for Excellence in Research |
2009 | Elected Fellow, American Association for the Advancement of Sciences (AAAS) |
Selected Publications
- St. John, P. C.; Hirota, T.; Kay, S. A.; Doyle, F. J. 3rd. Proc. Natl. Acad. Sci. USA 2014, 111, 2040. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. DOI: 10.1073/pnas.1323618111
- Hirota, T.; Lee, J. W.; St. John, P. C.; Sawa, M.; Iwaisako, K.; Noguchi, T.; Pongsawakul, P. Y.; Sonntag, T.; Welsh, D. K.; Brenner, D. A.; Doyle, F. J. 3rd, Schultz, P.G.; Kay, S.A. Science 2012, 337, 1094. Identification of small molecule activators of cryptochrome. DOI: 10.1126/science.1223710
- Lee, J. W.; Hirota, T.; Peters, E. C.; Garcia, M.; Gonzalez, R.; Cho, C. Y.; Wu, X.; Schultz, P. G.; Kay, S. A. Angew. Chem. Int. Ed. 2011, 50, 10608. A small molecule modulates circadian rhythms through phosphorylation of the period protein. DOI: 10.1002/anie.201103915
- Hirota, T.; Lee, J.W.; Lewis, W.G.; Zhang, E. E.; Breton, G.; Liu, X.; Garcia, M.; Peters, E. C.; Etchegaray, J. P.; Traver, D.; Schultz, P. G.; Kay, S. A. PLoS Biol. 2010, 8, e1000559. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. DOI: 10.1371/journal.pbio.1000559
- Zhang, E. E.; Liu, A. C.; Hirota, T.; Miraglia, L. J.; Welch, G.; Pongsawakul, P. Y.; Liu, X.; Atwood, A.; Huss, J. W. 3rd, Janes, J., Su, A. I., Hogenesch, J. B., Kay, S. A. Cell 2009, 139, 199. A genome-wide RNAi screen for modifiers of the circadian clock in human cells. DOI: 10.1016/j.cell.2009.08.031
- Members
- Yoshimura Group
- Yamaguchi Group
- Bode Group
- Crudden Group
- Frommer Group
- Itami Group
- Kamikouchi Group
- Hirota Group (collaborating with Kay)
- Kinoshita Group
- Ooi Group
- Tama Group
- Shimotohno Group (collaborating with Torii)
- Tsuchiya Group
- Yanai Group
- Laohavisit Group
- Mizuta Group
- Phung Group
- Kurihara Group
- Molecular Structure Center
- Live Imaging Center
- Chemical Library Center
- Peptide Protein Center
- Administrative Department
- Affiliated Researchers